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In addition, various ongoing animal studies may help further elucidate the pathogenic mechanisms and potential therapeutic targets for both early and advanced PSC

After screening titles and abstracts for eligibility, there were N = 313 papers for full-text screening

Hua S et al (2012) High expression of Mfn1 promotes early development of bovine SCNT embryos: improvement of mitochondrial membrane potential and oxidative metabolism

Future research should prioritize addressing the challenges related to curcumin's bioavailability and the translation of preclinical results into clinical achievements Moreover, modern curcumin based formulations with the improvement in efficiency, safety and stability demand ongoing innovations, through the Advancing curcumin-based formulations with improved efficacy, stability, and safety demands ongoing innovation, particularly through the implementation of nanotechnology and other most emerging fields of sciences

In a cohort study, the safety and efficacy profile of the LASV-specific mRNA vaccine was evaluated in human subjects following an intramuscular injection, receiving a prime-boost of 2 doses to complete the vaccination [307]